Provides Opinion & Testimony In:
Pharmacology, Biochemistry & Biophysics, Medicine, Infectious Diseases, Board Certified Internal Medicine, Emergency Medicine, Alzheimers Disease, Neurodegenerative Disease, Pharmacology, Antibiotics, Antiviral Drugs, HIV, AIDS, Sedatives, Antidepressants, Antipsychotics, Opiates, Analgestics, Antiinflammatory Agents, Vaccines, Wound Care, Adverse Reactions, Drug Drug Interactions, Pharmacokinetics, Laboratory Analysis, Spectroscopy, Fluorescence, Infrared, Mass Spectrometry, Computational Drug Design,t me see
Education:
1974-1978 University of Minnesota Degree: B.S. (Biochemistry)
1978-1982 Mayo Medical School Degree: M.D.
1981-1982 University of Washington Research in Biophysics and Bioengineering
1982-1985 Mayo Graduate School Program: Internal Medicine
1985-1989 Mayo Graduate School Program: Infectious Diseases
1986-1989 Mayo Graduate School Postdoctoral Fellowship, Biophysics
Board Certifications:
Internal Medicine (ABIM)
1985 Infectious Diseases (ABIM) 1989
Honors and Awards:
1978 Summa cum Laude, University of Minnesota
1979-1982 Joseph Collins Foundation Scholar
1988 General Mills Clinician Scholar
1989-1995 Markey Charitable Trust – Scholar in Biomedical Science
2006 Zenith Fellows Award, Alzheimer’s Association
2010 Distinguished Faculty Award, Graduate Group in Pharmacological Sciences, University of Pennsylvania Biomedical Graduate Studies
2011 Glenn Award for Aging Research
Professional Employment:
(Primary appointments underlined in bold)
1985 Emergency Department Physician, St. Olaf’s Hospital, Austin, MN
1986-1988 Emergency Department Physician, Olmsted Community Hospital, Rochester, MN
1987-1988 Infectious Diseases Consultant, Intermed Consultants P.A., Minneapolis, MN
1989-1992 Associate Consultant, Depts of Biochemistry and Molecular Biology, and the Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, MN
1990-1993 Assistant Professor of Biochemistry and Molecular Biology,
Mayo Graduate School of Medicine, Rochester, MN
1992-1993 Senior Associate Consultant, Department of Biochemistry and Molecular
Biology, and the Division of Infectious Diseases and Internal Medicine Mayo Clinic, Rochester, MN
1993-1999 Assistant Professor, Departments of Pharmacology, and Medicine, Infectious Diseases Section, University of Pennsylvania School of Medicine, Philadelphia, PA
1995-2001 Staff physician, Immunodeficiency Program, Infectious Diseases Division,
Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
1993-pres Associate, Johnson Foundation for Molecular Biophysics,
University of Pennsylvania School of Medicine, Philadelphia, PA
1999-2008 Associate Professor (with tenure), Depts of Pharmacology, and Medicine, Infectious Diseases Section, Univ of Pennsylvania School of Medicine, Philadelphia, PA
2003-2008 Associate Professor (with tenure), Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA
2008-pres Professor, Departments of Pharmacology, Biochemistry and Biophysics, and Medicine. University of Pennsylvania School of Medicine, Philadelphia, PA
Past Research Grant Support:
Markey Charitable Trust:
“Spectroscopic and Computational Studies of Biological Surface Phenomena”, 1989-1996
NIGMS R01 (P.I.): “Simulated Molecular Recognition” 7/1993 – 6/1996
NHLBI R01 (Co.I.): “Protease Specificity in the Control of Coagulation” 2/1992–1/1997
NIGMS R01 (P.I.): “Membrane Recognition” 5/1997 – 5/2002
NHLBI R01 (P.I.): “Processing of High Density Lipoproteins” (9/2002 – 8/2006)
NIAID R01 (P.I.): “Structure-based Antimicrobial Design” (4/2002–3/2006)
NINDS R01 (P.I.) “Oxidative Lipid Stress in the Brain” (through 6/30/2016)
NIGMS R01 (P.I.) “Structure Determination by Vibrational Spectroscopy” (through 3/31/2019)
Alzheimer’s Association “Maternally Determined Predisposition to Oxidative Stress” (through 9/30/2016)
NIA R01 (P.I.): “Membrane-mediated Amyloidogenesis” (2003–2008)
NIA R56 (P.I.): “Membrane-mediated Amyloidogenesis” (2009-2010)
Alzheimer’s Association: “Structural Determinations in Amyloid Intermediates and Mature Fibrils” (8/2002–9/2005)
Alzheimer’s Association: “The Structure of Neurotoxic Intermediate Forms of Amyloid Beta Proteins” (active through 9/2008)
Am. Heart Assoc. (P.I.): “Structural Analysis of Coagulation Protease Recognition” (6/1991 – 5/1993)
Am. Heart Assoc. (P.I.): “Lipid Peroxidation and Thrombogenesis” (6/1996–5/1998)
Am. Heart Assoc. (P.I.): “Lipid Peroxidation and Thrombogenesis” (1/1999 – 12/2001)
Dept. of Defense (Co.I.): “Rational Design of New Agents for the Treatment of Breast Cancer” (ended 9/2001)
Dept. of Defense (Co.I.): “Rational Design of New Agents for the Treatment of Prostate Cancer” (ended 10/2001)
American Health Assistance Foundation “Oxidative stress and amyloidogenesis” (ended 12/31/2013)
Glenn Foundation “Membrane-Mediated Amyloidogenesis” (ended 12/31/2013)
Current Grant Support:
NIA R01 (P.I.) “Posttranslational Protein Modification in Alzheimer Pathology” (to 12/31/2022)
NIH Study Section Service:
1999 Physical Biochemistry (Special Study Section)
1999-2003 Biomedical Research Subcommittee for Pharmacology, Biophysics, and MD-PhD Training (regular member)
2000 Biophysical Sciences (Special Study Section for Member Applications)
2002-2003 Bioterrorism & Therapeutics Study Section, ad hoc
2003 Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases (Special Study Section)
2004 Biophysics and Biophysical Chemistry (BBCB), ad hoc
2004 Physical Biochemistry (PB), ad hoc
2006-2009 Biochemistry and Biophysics of Membranes (BBM), regular member
2007 Biophysics of Neural Systems (BPNS), ad hoc
2010-2019 Member, College of the Center for Scientific Review
2015-2019 Biophysics of Neural Systems (BPNS), regular member
2017-2019 Biophysics of Neural Systems (BPNS), Chair
Overseas Positions:
1985-1986 Base Physician, Summer Institute of Linguistics, Papua New Guinea
1986 Consultant for Infectious Disease and Microbiology, Bangalore, India
1992-1993 Visiting Professor, Weizmann Institute of Science, Rehovot, Israel
Leadership Roles at Penn (current active roles in bold)
1999-pres Applicant interviewer, Biochemistry and Molecular Biophysics program
2004-2006 Member, Academic Review Committee, Pharmacological Sciences program
2006-pres Chair, Academic Review Committee, Pharmacological Sciences program
2004-2009 Member, University Research Foundation Review Committee
2002-2004 Elected member, Medical Faculty Senate Steering Committee
2006-2008 Elected member, Medical Faculty Senate Steering Committee
2007 Chair nominee, Medical Faculty Senate Steering Committee
2010-2014 Member, Limited Application Selection Committee
2011-pres College House Faculty Fellow (2011-2012, Ware; 2012-pres, Fisher-Hassenfeld)
Current Principal Teaching Activities
Course Co-director Medical Pharmacology (PHRM 600/624)
Lecturer Membrane Biophysics (BMB 509)
Lecturer Molecular Basis of Disease (BIOM 502)
Organizing Roles in Scientific Meetings, Societies, Publications, and Boards:
Clinical practice interests:
Clinical pharmacology, especially adverse drug reactions and drug-drug interactions Infectious diseases, especially antimicrobial pharmacology and emerging resistance HIV / AIDS, and International Travel Medicine
Research interests:
Pathophysiology of oxidative damage and protein misfolding in neurodegenerative diseases; Lipoprotein structure; Molecular recognition and rational/computer-aided drug design; Structure and function of glycopeptide and polypeptide antibiotics.
Other interests:
Private Pilot (Instrument rating)
